Commonly mutated gene shown to drive therapeutic resistance in HER2-positive breastcancer CUAnschutz
In summary, development of a biomarker for PI3Ki is an evolving field. Currently, it is prudent to consider all non-CDxmutations on a case-by-case basis, recognizing that not all mutations identified by NGS assays have confirmed deleterious effects on protein function and a verified ability to respond to alpelisib. In the setting of certainalterations, it is biologically feasible that HER2+ disease may derive a unique benefit from alpelisib or other PI3Ki.
In conclusion, the PI3K pathway is fundamentally important for tumorigenesis of HER2+ tumors and escape from HER2i that limits the survival of patients with HER2+ disease. Despite the challenges faced in the clinical testing formutations and the high toxicities and abandonment of many PI3Ki, clinical development of PI3Ki and their predictive biomarkers in HER2+ breast cancer is ongoing.
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