Intellegens, a company applying machine learning (ML) to accelerate innovation in R&D, today announced that it has secured a £1.6m grant from Innovate UK, part of UK Research and Innovation (UKRI), to apply ML in the emerging field of oligonucleotide therapies.
Aug 30 2023Reviewed by Megan Craig, M.Sc. In collaboration with the Centre for Process Innovation , the two-year project will augment and validate the company’s ML technology, Alchemite™, as a tool to enhance productivity and yields of oligonucleotide therapeutic manufacture through performance prediction and optimisation of quality control strategies.
Offering high specificity with the ability to treat an extremely broad range of diseases, oligonucleotides represent a promising therapeutic option in pharmaceutical research. However, their full potential is yet to be realised, as manufacturing knowledge and experience are limited outside a small number of specialist companies. Therapeutic oligonucleotides are large, complex molecules, requiring a multi-stage synthetic process alongside significant purification and analysis steps.
The collaboration will validate Alchemite as a tool to improve productivity in oligonucleotide process development and manufacturing workflows. Through automated data processing and process modelling, Alchemite will be used for analysis of large datasets, predictions of process performance, and subsequent optimisation of quality control strategies and process parameters.
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