Researchers identified 323 peptide-based antimicrobials from the human microbiome, with 71% showing significant antibacterial activity, and the lead peptide, prevotellin-2, matching the efficacy of polymyxin B in both in vitro and in vivo models.
By Pooja Toshniwal PahariaReviewed by Benedette Cuffari, M.Sc.Aug 25 2024 Study: Mining human microbiomes reveal an untapped source of peptide antibiotics. Image Credit: nobeastsofierce / Shutterstock.com
To date, few reported cases of resistance against antimicrobial peptides have been published, which has led researchers to become increasingly interested in their potential clinical applications. Several AMPs, the most common of which include bacitracin, colistin, and polymyxin B, have already been successfully approved for clinical use.
About the study Using computational techniques, the researchers assessed the antibacterial capabilities of 444,054 peptides from 1,773 human metagenomes listed in the Human Microbiome Project . To refine the list, 78 peptides were identified and assessed for their antibiotic activity against several high-priority pathogenic and gut commensal bacteria in vitro, following which five peptides were selected for in vivo evaluation.
The minimum inhibitory concentration of selected SEPs was identified to evaluate their anti-infective activities in murine models of skin abscesses and deep-seated thigh infections using Acinetobacter baumannii. The secondary structures of active SEPs were analyzed using ColabFold and circular dichroism to determine whether these peptides could collectively target bacteria. Checkerboard experiments on SEP pairs generated from similar sites were also performed to determine molecular interactions' fractional inhibitory concentration index .
Microbiome Peptides Amino Acid Antimicrobial Resistance Bacteria Cell In Vitro In Vivo Membrane Public Health Skin
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Nans against Nazis: Defiant Scouse pensioner, 71, takes to the frontline in Liverpool to protect...Protestors gather outside mosque in Sunderland following riots in Southport after knife attack. Three young girls were killed after a teenager attacked their dance class, sparking riots in Southport.
Read more »
Rarely-seen Young Einstein star Yahoo Serious, 71, unrecognisable on day outWild-haired star Yahoo Serious, who was huge in the '80s and '90s with movies like Young Einstein, has been spotted out – but he's so different compared to his Hollywood heyday
Read more »
Asylum seeker jailed for attempted murder after stabbing his own solicitor, 71, in the chestAn asylum seeker has been jailed for attempted murder after stabbing his own solicitor.
Read more »
Knife thug tried to kill own lawyer stabbing him in chest during office assaultEsaya Neguse attacked Muhammad Shoaib, leaving the 71-year-old fearing he was going to die.
Read more »
Three cars destroyed in Clydebank amid deliberate blaze on busy streetEmergency services were called to Glasgow Road at around 3.50pm on Sunday, August 3, following reports a white Audi A6, red Vauxhall Mokka and blue BMW 323 were ablaze.
Read more »
Cracking the carb code: Researchers create new glycemic index database to improve dietary awarenessKaren Della Corte, BYU nutrition and dietetics professor, recently authored a new study, published in The American Journal of Clinical Nutrition, that developed a national glycemic index (GI) and glycemic load (GL) database to offer insights into the evolving quality of carbohydrates consumed in the United States, something that hadn't been done...
Read more »