Could Vitamin B6 Reduce Anxiety and Depression?

Interview conducted by Emily Henderson, B.Sc.Jul 19 2022 Thought LeadersDr. David FieldAssociate ProfessorUniversity of Reading

I wanted to find out which individual ingredients in the marmite were driving the effect, and B6 and B12 were the most plausible candidates, so I decided to team up with Innopure, who donated vitamin tablets, and test them individually versus placebo.

Another thing that makes my study different is that as well as measuring anxiety and depression because I hypothesized that the underlying mechanism by which B6 might help these things might be increased GABA, I also included in my study laboratory tasks that give you a handle on whether GABA in the brain has changed; earlier studies just measured the anxiety and depression.

Foods high in B6 include chickpeas, liver, tuna, salmon, chicken, fortified breakfast cereals, banana, turkey, and yeast-based spreads. But there are many more.Your latest research focused on reducing anxiety and depression through vitamin B6 supplements. Please can you tell us more about your study and its results? By randomly allocating participants to three groups, we compared the effects of taking a high dose of Vitamin B6 to that of a placebo or a high dose of Vitamin B12.

Despite your study being small, it demonstrated the power of nutrition-based interventions. What are some advantages of individuals trying these interventions first instead of turning to medication? There is currently no data comparing B6 supplements to other treatments for anxiety and depression, so I can only answer this with plausible speculations I'd like to test by collecting data.

What are the next steps for you and your research? We have shown that taking a high dose of Vitamin B6 can influence the balance of an important metabolic pathway in the brain, causing a small reduction in anxiety in our participants. But the most important implication can be seen by thinking beyond this to some other micronutrients that might also influence other metabolic pathways relevant to calming the brain.

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