Can a disrupted gut microbiota contribute to anorexia nervosa pathogenesis? anorexianervosa eatingdisorder gutmicrobiota microbiome metabolomics neurotransmitters mentalhealth bacterialvariants faecaltransplantation NatureMicrobiol
By Pooja Toshniwal PahariaApr 18 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in the journal Nature Microbiology, researchers investigated whether intestinal microbial alterations contribute to anorexia nervosa pathogenesis.
About the study In the present study, researchers assessed the association between the intestinal microbiome and AN. Further, the team evaluated the growth dynamics of gut bacteria by calculating peak-to-trough ratios using the metagenomic dataset. The functional modules of gut bacteria were identified using gut-brain modules and gut metabolic modules . Differences in bacterial genomics were explored based on the Canberra distance of bacterial structural variant profiles.
Absolute Brachyspira count showed a positive association with ‘drive for thinness’ markers in anorexia nervosa. Median values for PTR markedly differed between individuals with AN and controls. Women with AN were leaner, had lower fasting serological insulin, glucose, and C-reactive protein levels, and were more sensitive to insulin than controls.
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