Moderna booster candidate shows strong response against Omicron subvariants

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CAMBRIDGE — Moderna said on Wednesday (June 22) that an updated version of its Covid-19 vaccine designed to target the Omicron variant also generated a strong immune response against the fast-spreading Omicron subvariants BA.4 and BA.5, which have gained a foothold in the United States (US) in recent weeks.

The updated vaccine, which Moderna is hoping will be approved for use as a booster shot for the fall, is a bivalent vaccine, meaning it contains vaccine designed to target two different coronavirus variants — the original variant from 2020 and the Omicron variant that was circulating widely last winter.

"This is a strong, powerful antibody response," Moderna Chief Medical Officer Paul Burton said at a news conference."It is probably long lasting and I think the conclusions are that boosting or primary vaccination with really could be a turning point in our fight against SARS-cov-2 virus." The company plans to submit applications to regulators in the coming weeks to ask for approval of the shot — which it calls mRNA-1273.214 — for the fall season.

The US Food and Drug Administration plans to hold a meeting of outside experts next week to discuss the best composition of booster shots for the fall.

 

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