Lymphoma – a cancer of the blood – is one of the most common types of cancer in Singapore, with two or three new cases diagnosed every day.
However, a local group of experts believe that by the end of this year, a test costing less than $1,000 will be able to determine whether a patient suffering from a particular subtype of lymphoma will respond to the treatment. “The genetic variation, known as PD-L1 3’UTR SR, increases the growth of a type of protein called PD-L1 on individual cancer cells and shields them from attacks by the body’s immune cells,” said Dr Ong Choon Kiat, a scientist from the National Cancer Centre Singapore involved in the research.Blocking these proteins with monoclonal antibodies allows the cancer cells to be rediscovered and destroyed by the immunity cells.
Patients with these gene alterations were also found to respond better to immunotherapy than patients without. Professor Lim Soon Thye, Symphony’s corresponding principal investigator, said: “It is important to understand that not all patients will respond to immunotherapy, and the population of patients who respond to this treatment will depend very much on the type of cancer.
Source: Healthcare Press (healthcarepress.net)
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