The results were the same whether people started treatment within three or five days of developing symptoms.
But these are all administered via an intravenous infusion, adding to the complexity and cost of treatment, putting them outside the reach of many developing countries. The antibody therapies are of greater concern because they target the spike protein that the coronavirus uses to enter cells, and Omicron is characterised by 30 or more changes to that region.
The WHO in December advised against treating COVID-19 patients with convalescent plasma, a basic version of antibody therapy that involves collecting plasma, the liquid part of blood, from people who have recovered from COVID-19 and developed antibodies to the coronavirus, and transfusing it into those who are still sick.
Typically, these studies are designed to show that patients randomly assigned to get the drug do better than those in a control group who do not, and that the results are not a product of chance.
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