The EMA announcement is a fresh setback for the vaccine, which is sold at cost, for a few dollars a dose, and is by far the cheapest and most high-volume launched so far. After extensive use in Britain and mainland Europe, it is set to be the mainstay of vaccination programmes in much of the developing world.
Both the EMA and the World Health Organization have said the benefits outweigh the risks of the vaccine. But the shot has faced questions since late last year, when the drugmaker and Oxford University published data from an earlier trial with two different efficacy readings as a result of a dosing error.
Scientists are exploring several possibilities that might explain the rare brain blood clots. One theory suggests the vaccine triggers an unusual antibody in some rare cases; other investigators are looking into a possible link with birth control pills.
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