Early research suggests Merck cancer drug may target dormant HIV

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Researchers studying Merck \u0026 Co Inc\u0027s cancer drug Keytruda for HIV patients who also have cancer say the immunotherapy may help displace the virus from human immune cells, offering an intriguing area of study for treatment of chronic HIV infection. Antiretroviral treatments now allow many HIV patients

Researchers studying Merck & Co Inc's cancer drug Keytruda for HIV patients who also have cancer say the immunotherapy may help displace the virus from human immune cells, offering an intriguing area of study for treatment of chronic HIV infection.

Keytruda, also known as pembrolizumab, is a monoclonal antibody designed to help the body’s own immune system fend off cancer by blocking a protein known as Programmed Death receptor used by tumors to evade disease-fighting cells. An international research collaboration said it has found evidence that pembrolizumab can reverse HIV latency - the ability for the virus to"hide" inside cells of people living with HIV on antiretroviral therapy.

"Pembrolizumab was able to perturb the HIV reservoir," Professor Sharon Lewin, director of the Peter Doherty Institute for Infection and Immunity in Melbourne, Australia, said in a statement.

 

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