Do You Want to Be a Vaccine Volunteer?

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You may be surprised by the commitment and risks that a trial entails. Here’s what you need to know.

Maybe you are an altruist looking for a way to help fight the coronavirus. Maybe you are hoping to be among the first to try an experimental vaccine. Or maybe you are just bored or could use a few hundred dollars.

Right now, for example, Moderna is looking to enroll around 30,000 volunteers. ClinicalTrials.gov also lists COVID-19 vaccine studies at different phases.There are three primary phases of a vaccine trial. A phase one trial is focused on safety. If you participate, you are likely to be among the first humans to try the vaccine. Researchers will want to track whether it affects you negatively, such as making you feverish or dizzy.

If you think about a vaccine developer’s desired immune response like a bar that a pole-vaulter needs to clear to move to the next round, “you want to see that you got over the bar,” he said. To extend the metaphor, the pole-vaulter won’t know if clearing that bar was enough to win, he said. Just because a vaccine has generated an immune response doesn’t mean it was sufficient to protect anyone, he said.

Story continues“What you are doing is providing compensation for time and trouble,” said Dr. Daniel Hoft, director of the Saint Louis University Center for Vaccine Development. “Insurance companies will rarely pay anything if you are hurt in an experiment,” he said. So ask a lot of questions first. “If I get injured, what happens?” is among those he recommends.

The approach is controversial because COVID-19 has no cure and can be fatal. But it is also tantalizing because it promises to dramatically speed up research.

 

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