by extending ultra-small tentacles that reach into immune cells and pull out their powerpack, the mitochondria.
In the research, scientists co-cultured breast cancer cells and immune cells, such as T cells, and found using cutting-edge microscopy techniques that the two cells were physically connected via tiny tendrils with widths mostly in the 100 nanometre to 1,000 nanometre range, several thousand times smaller than the width of a single human hair.
The researchers then stained mitochondria, which provide energy for cells, from the T cells with a fluorescent dye. They could see that the mitochondria, stained bright green, were pulled out of the immune cells through the nanotubes, and into the cancer cells. “This is a completely new mechanism by which cancer cells evade the immune system and it gives us a new target to go after,” added Dr Sengupta, who is also a co-founder and owns equity in drug development companies Vyome Therapeutics, Akamara Therapeutics and Invictus Oncology, and receives fees from firms Famygen and Advamedica.The scientists then injected an inhibitor of nanotube formation into mouse models used for studying lung cancer and breast cancer.
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