BARCELONA: AstraZeneca presented results on Monday for a trial of its Lynparza drug against prostate cancer, which it hopes could lead to wider regulatory approval for the treatment for use against more forms of the disease.
In the prostate cancer study researchers gave Lynparza to men with metastatic disease that had worsened despite at least two forms of hormone therapy, and compared time to progression with a reference group of patients on standard hormone therapy. Lynparza, and other drugs in the drug class of PARP inhibitors that it belongs to, are designed to block what is left of the DNA repair mechanism so cancer cells fail to replicate.The trial was restricted to patients that were found to have a range of genetic mutations that hamper DNA repairs, grouped together under the term homologous recombination deficiency .
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