US FDA to take up Moderna, J&J COVID-19 booster questions this week

It's been one of the biggest ongoing questions about vaccines since three different products hit the US -- is it safe, and even desirable, to mix different vaccine types?

Researchers have been trying a variety of combinations."We first started off looking at people who have previously received Johnson & Johnson, Moderna and Pfizer and boosting those with an additional dose of Moderna vaccine," she said. The researchers have also tried boosting volunteers with Pfizer's and Johnson & Johnson's vaccine.

One head-to-head study led by the US Centers for Disease Control and Prevention found Moderna's vaccine was slightly more effective than Pfizer's in real-life use in keeping people out of the hospital.FDA staff were circumspect in documents posted ahead of Thursday's meeting."Some real world effectiveness studies have suggested declining efficacy of Moderna COVID-19 Vaccine over time against symptomatic infection or against the Delta variant, while others have not.

"Based on the recent data, it can be assumed that the administration of the booster dose will result in increased protection against symptomatic infection, increased strength and breadth of immune responses against current variants, and increase of the magnitude of protection against severe disease across populations," the company says in its application.

The committee will reconvene at 3:30 p.m. Friday to discuss the question of mix and match boosters -- although a vote is not scheduled on that question.

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