No 'gay gene' can predict sexual orientation, study says

Instead, a host of genetic and environmental factors play a role, according to a study published Thursday in Science Magazine. The findings provide insight into the complex genetics underlying human sexuality. But they do not explain it, wrote the international team of researchers who analyzed genetic data gathered from almost half a million people.

Same-sex attraction appears to run in families, and identical twins are more likely to be aligned in their sexuality than either fraternal twins or other siblings, noted the researchers. Both these factors suggest genetic influences are at play. Researchers conducted analyses of data for 477,522 participants in surveys from the UK and US, and then performed comparison testing among some 15,142 people in the US and Sweden. Different base studies provided different survey results. Some surveys recorded whether participants ever had a same-sex partner, and others recorded how people identified their orientation.

Several hundred genes appeared to have an influence on sexuality. Five variants showed significant effects, the researchers said. When tested, though, these genetic factors combined accounted for 8% to 25% of same-sex behavior participants reported, according to the researchers.This could reflect the influence of hormones or possibly social differences among gays, lesbians, and bisexuals, the study authors speculated.

Still, the study showed that sexual orientation"is not a single dimension and same-sex attraction is not inversely related to opposite-sex attraction, arguing for a more nuanced social understanding of sexual orientation that also includes bisexuality and asexuality," said Neely.Sexual orientation"is influenced by genes but not determined by genes," said Brendan Zietsch, senior author of the study and a genetic researcher at the University of Queensland.

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