, as revealed by molecular dating, throughout Southeast Asia and Yunnan, and that different species of bats could have exchanged these viruses in the caves they inhabit.
Chinese researchers have been searching for Sarbecoviruses throughout the country for about 15 years. They found more than 100 SARS-CoV-like viruses but only two related to SARS-CoV-2. The new data thus validates the hypothesis that SARS-CoV-2-like viruses are present mostly in Southeast Asia, while SARS-CoV-like viruses are dominant in China.
Number of Covid-19 patients per million inhabitants and deaths per million inhabitants for the different countries of Southeast Asia.The data in the figure above indirectly support the hypothesis that the SARS-CoV-2 group actually originated in mainland Southeast Asia. Indeed, human populations in Cambodia, Laos, Thailand and Vietnam appear to be much less affected by the Covid-19 pandemic than other countries in the region, such as Bangladesh, Myanmar, Malaysia, the Philippines and Indonesia.
Even if the viruses sequenced in pangolins are not that close to SARS-CoV-2 , they indicate that at least two Sarbecoviruses could have been imported into China well before the Covid-19 epidemic. Indeed, it has been shown that pangolins from Southeast Asian countries have contaminated each otherThe question remains on how the pangolins became infected initially.
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