Female reproductive hormones could help protect against severe forms of COVID-19

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CDNTopStories Dr. Graziano Pinna’s study was published on the Trends in Endocrinology and Metabolism journal on Nov. 8, focusing on pregnant women and the differences observed between men and women concerning the most serious forms of the disease.

comes from the United States and concerns women. A University of Illinois in Chicago researcher showed that feminine sexual steroids could have an anti-inflammatory effect that may protect women from severe forms of COVID-19.

Pinna discovered that sex steroid hormones estrogen and progesterone but also allopregnanolone, a progesterone metabolite, played an anti-inflammatory role, stimulating antibody production and promoting respiratory epithelial cell repair while inhibiting the ACE2 receptor, the access point for SARS-CoV-2. In other terms, these sex steroids could protect women from certain symptoms.

“Hormones that help sustain the pregnancy — like progesterone — are 100 times more concentrated in a pregnancy’s third trimester. Estradiol, allopregnanolone, and progesterone all have important anti-inflammatory functions and are involved in resetting the immune system. This suggests that pregnant women became symptomatic, and some were even admitted to the ICU, after delivering their babies because of the rapid drop in these hormones,” said Pinna. “The correlation was really striking.

 

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