Blood clots and AstraZeneca COVID-19 jabs: Experts abroad explain

Persistent questions on whether rare but serious blood clots among those getting the AstraZeneca jab against Covid-19 are more frequent than in the general population, and what causes them if they are, have continued to undermine confidence in the beleaguered vaccine.

In mid-March Germany's medicines regulator, the Paul Ehrlich Institute , was the first national health authority to flag what they described as an aberrantly high number of cases involving these rare cerebral blood clots, mostly in younger and middle-aged women. For its part, France's ANSM -- pointing to "the very unusual type of thrombosis, a similar clinical profile, and similar timing of onset" -- said there was a "small" risk.As of March 31, the EMA identified 62 cases of cerebral venous sinus thrombosis in the world -- 44 of them in Europe -- among 9.2 million doses of AstraZeneca administered.

Britain -- where AstraZeneca has been administered more than in any other country -- registered 30 cases as of Saturday, including seven fatalities, across a total of 18.1 million doses."We would all prefer to have drugs that are 100 percent safe but they don't exist," Adam Finn, a professor of paediatrics at University of Bristol, told the London-based Science Media Centre last week, commenting on renewed bans of the AstraZeneca vaccine in Germany and elsewhere.

Notwithstanding, after some countries temporarily paused the AstraZeneca jab in mid-March, several countries have now suspended the vaccine again.

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