BioNTech and Pfizer's COVID-19 vaccine shows potential in human trial

FRANKFURT - A COVID-19 vaccine developed by German biotech firm BioNTech and US pharmaceutical giant Pfizer has shown potential and was found to be well tolerated in early-stage human trials, the companies said Wednesday.

BioNTech's shares were up 4.6 percent, after rising as much as 19 percent to reach their highest in more than 3 months. It said the higher of the 2 doses - both administered via 2 injections within 3 weeks of one another - was followed by a short fever in 3 out of 4 participants after the second shot.

He said larger trials were being prepared to show whether this translates into protection against a real infection. Early-stage human trials of vaccines are designed to measure certain antibodies and other immune markers in the blood as an indicator of the body's readiness to fight an infection that then requires further validation.

If it eventually gets marketing approval, the companies are gearing up to make up to 100 million doses by the end of 2020 and another 1.2 billion doses by the end of 2021 at sites in Germany and the United States.The manuscript with the preliminary data from the clinical trials, which were launched in April and May, is under peer review for publication in a scientific journal, BioNTech said.

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