Scientists uncover why cancer patients with ARID1A gene mutations are more likely to respond to immunotherapy, discovering ARID1A mutations invite cancer-fighting immune cells into tumors by triggering an antiviral-like response.
Salk researchers uncover why patients with ARID1A mutations are more likely to respond to cancer immunotherapy; findings could improve future cancer care and drug development Their findings could help improve cancer care and drug development for many cancer types, including endometrial, ovarian, colon, gastric, liver, and pancreatic cancers.
"This could really make a difference in patient outcomes from cancer treatment," says Associate Professor Diana Hargreaves, senior author of the study."Thesemutation cancer patients are already having an immune response, so all we need to do is upregulate that response using immune checkpoint blockade to help them destroy their tumors from the inside."mutations responded well to immune checkpoint blockade, the exact relationship between the two remained unclear.
Other authors include Jawoon Yi, Shitian Li, Samuel Rivera, Jingting Yu, Mannix Burns, Helen McRae, Braden Stevenson, Josephine Ho, Kameneff Bojorquez Gastelum, Joshua Bell, Alexander Jones, Gerald Shadel, and Susan Kaech of Salk; Marianne Hom-Tedla and Katherine Coakley of Salk and UC San Diego; Ramez Eskander of UC San Diego; and Emily Dykhuizen of Purdue University.
Researchers want to improve their understanding of the immune environment in ovarian cancer in hopes of making immunotherapy an option for these patients. Researchers now report on key ...
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