A modified seed aggregation assay detects minute amounts of serum α-synuclein seeds in individuals with Synucleinopathy, demonstrating high performance as a DiagnosticBiomarker.
This work was supported by the Japan Agency for Medical Research and Development ; the Multicenter Alliance for Brain Biomarkers ; Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science; the Visionary Council on the Moonshot Research and Development Program ; grants-in-aid from the Research Committee of CNS Degenerative Disease, Research on Policy Planning and Evaluation for Rare and Intractable Diseases, Health, Labor, and Welfare Sciences Research Grants;...
Ayami Okuzumi, Taku Hatano, Shin-ichi Ueno, Yoko Imamichi-Tatano, Haruka Kimura, Yuanzhe Li, Manabu Funayama, Shinji Saiki, Daisuke Taniguchi, Taiji Tsunemi & Nobutaka HattoriGen MatsumotoShuko Nojiri Laboratory of Morphology and Image Analysis, Biomedical Research Core Facilities, Juntendo University Faculty of Medicine, Tokyo, JapanAkihide KondoTakeshi Fukuhara & Nobutaka HattoriTransversal Translational Medicine, Luxembourg Institute of Health , Strassen, LuxembourgLuxembourg National Center of Pathology , Laboratoire National de Santé ; Department of Cancer Research , Luxembourg Institute of Health ; Luxembourg Centre of Neuropathology , Luxembourg Centre for Systems Biomedicine...
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