Recent findings yield good news about bridging the urban-rural healthcare gap.
A growing body of research suggests that clinicians can offer chimeric antigen receptor T-cell therapy safely and effectively on an outpatient basis — a positive development as clinicians strive to expand access beyond metropolitan areas. “The future of CAR T -cell therapy lies in balancing safety with accessibility,” said Rayne Rouce, MD, a pediatric oncologist at Texas Children's Cancer Center in Houston, Texas, in an interview.
“Commercialization of CAR T-cell therapy brought hope that access would expand beyond the major academic medical centers with the highly specialized infrastructure and advanced laboratories required to manufacture and ultimately treat patients,” Rouce said.
A statistic tells the story of the urban/community divide. CAR T-cell therapy administration at academic centers after leukapheresis — the separation and collection of white blood cells — is reported to be at around 90%, while it’s only 47% in community-based practices that have to refer patients elsewhere, Linhares noted. that explored administration of lisocabtagene maraleucel in 82 patients with relapsed/refractory large B-cell lymphoma. The findings were published Sept.
Specifically, reasons for inpatient monitoring were disease characteristics including tumor burden and risk of adverse events; psychosocial factors including lack of caregiver support or transportation; COVID-19 precautions ; pre-infusion adverse events of fever and vasovagal reaction; and principal investigator decision due to limited hospital experience with CAR T-cell therapy.
Non-Hodgkin Lymphoma NHL Biologic Therapy Biologics Chimeric Antigen Receptor T-Cell Therapy Chimeric Antigen Receptors Chimeric Immunoreceptors Chimeric T-Cell Receptors Artificial T-Cell Receptors CAR T Chimaeric Antigen Receptor T-Cell Therapy Chimaeric Antigen Receptors Chimaeric Immunoreceptors Chimaeric T-Cell Receptors B-Cell Lymphoma
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