In a first renal outcome trial of its kind, the SGLT2 inhibitor showed favorable outcomes in the most advanced stages of CKD.
SAN DIEGO — Dapagliflozin provides significant benefits in the treatment of chronic kidney disease even when initiated in patients with the most severe stages of the disease who are typically excluded from clinical trials, new research shows.
In patients with CKD stage 4-5, dapagliflozin plus integrated CKD care improved total eGFR slope composite renal outcomes, composite renal andThis is"the first SGLT2 inhibitor renal outcome trial to include patients with an estimated glomerular filtration rate less than 20 mL/min/1.73 m and heart failure. They have typically been excluded from most clinical trials, or are included in only very small numbers, Hung explained.
By taking the next step and focusing specifically on patients with stage 4 and 5 CKD in their new trial, Hung and colleagues"recognized this evidence gap in which we have limited data in patients with an eGFR less than 30 mL/min/1.73 mTheir findings underscore that"we can start dapagliflozin in patients with advanced CKD and an eGFR less than 20 mL/min/1.
Hung has received research support from AstraZeneca. Wheeler's disclosures include honoraria and/or consultancy fees from Amgen, AstraZeneca, Astellas, Bayer, Boehringer Ingelheim, Eledon, Merck, Menarini, Mineralys, Pathaly, ProKidney, and Vifor.
Chronic Kidney Failure CKD - Chronic Kidney Disease Chronic Kidney Disease CKD Renal Failure Renal Insufficiency Kidney Insufficiency Kidney Failure Renal Impairment Acute Kidney Injury AKI Acute Renal Failure Acute Kidney Failure Renal Trauma Renal Injury Kidney Trauma Renal Disease Kidney Disease Kidney Disorder Renal Disorder Nephropathy Kidneys Heart
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