Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases, including cancer and neurodegenerative disorders.
Molecular gardening: New enzymes discovered for protein modification pruning." ScienceDaily. ScienceDaily, 19 December 2024. <www.sciencedaily.com
Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ... New research could one day lead to therapies that prevent or treat diseases and infections tied to a protein that's found in all human cells. A study describes how the protein ubiquitin is modified ...
Recent failed clinical trials of a drug designed to clear the mutant Huntingtin protein that causes Huntington's disease heightens the need for new approaches for the devastating, incurable, ... In many neurodegenerative diseases, proteins clump in the brain, forming so-called amyloid fibrils. Yet there exists a cellular defence mechanism that counteracts this process and even dissolves ...Brain Cells Remain Healthy After a Month on the International Space Station, but Mature Faster Than Brain Cells on Earth
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