A new study challenges the understanding of cancer cell classification by revealing that healthy breast tissues can contain cells with unusual chromosome copies, similar to cancerous cells. This finding could impact early breast cancer detection methods.
Most cancer cells have too many or too few chromosomes, distinguishing them from normal cells. But a new study shows that healthy breast tissues can also have cells with unusual copies of chromosomes.
In the new study, published Nov. 20 in the journal Nature, scientists found that about 3% of the cells in the inner lining of a healthy breast, known as breast epithelial cells, are aneuploid. More than 80% of these aneuploid cells had changes in their DNA structure that may alter gene expression — how genes are switched on or off — and lead to diseases, such as invasive cancer.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.Navin and his team analyzed more than 83,000 breast epithelial cells from 49 healthy women who had undergone breast reduction surgery and did not have cancer. They profiled the genetic makeup of these women and then used another test, called the assay for transposase-accessible chromatin sequencing , to look for any genetic anomalies characteristic of an invasive cancer.
Breast Cancer Aneuploidy Genetics Chromosome Changes Cell Biology
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