Vaccine offers option for patients with antibiotic-resistant UTIs

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New vaccine offers option for patients with antibiotic-resistant UTIs — via healthing_ca

Recurrent UTIs are more common in women — particularly post-menopausal women — than men and is generally viewed as a women’s health issue even though it is seldom discussed, De Nisco said. Canadian women make around 500,000 visits per year to doctors seeking treatment for a UTI,. The issue generally arises when E. coli living on the skin outside the body manages to enter the urethra, travel to the bladder and cause an infection.

“Every subsequent infection becomes more difficult to treat,” De Nisco said. “Even if you clear the bacteria from the bladder, populations persist elsewhere and usually become resistant to the antibiotic used. When patients accumulate antibiotic resistances, they’re eventually going to run out of options.”

“We throw the whole kitchen sink at them because that’s what your body normally sees when it becomes infected,” said Jeremiah Gassensmith, an associate professor of chemistry and biochemistry at the University of Texas at Dallas. “Vaccines using whole-cell dead bacteria haven’t succeeded because the cells typically don’t last long enough in the body to produce long-term, durable immune responses.

 

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