Tweaked COVID-19 vaccines in testing aim to fend off variants

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Dozens of Americans are rolling up their sleeves for a third dose of COVID-19 vaccine -- this time, shots tweaked to guard against a worrisome mutated version of the virus.

Make no mistake: The vaccines currently being rolled out across the U.S. offer strong protection. But new studies of experimental updates to the Moderna and Pfizer vaccines mark a critical first step toward an alternative if the virus eventually outsmarts today's shots.

Already an easier-to-spread version found in Britain just months ago has become the most common variant now circulating in the United States, one that's fortunately vaccine-preventable. "The earlier one, it was a great success and, you know, millions of people are getting vaccinated now," Smith told The Associated Press. "If we're helping people with the old one, why not volunteer and help people with the new one?"

Separately, the Food and Drug Administration has given Pfizer and its German partner BioNTech permission to start similar testing of their own tweaked vaccine. The companies called it part of a proactive strategy to enable rapid deployment of updated vaccines if they're ever needed. The good news: It's fairly easy to update the Moderna and Pfizer vaccines. They're made with a piece of genetic code called messenger RNA that tells the body how to make some harmless spike copies that in turn train immune cells. The companies simply swapped out the original vaccine's genetic code with mRNA for the mutated spike protein -- this time, the one from South Africa.

 

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Big Pharma not letting go of this gold mine. We'll have fourth and fifth versions before end of year.

'The researchers found the prevalence of B.1.351 among patients who received two doses of the vaccine was about eight times higher than those who were unvaccinated.'

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