Seven vaccine makers’ COVID-19 boosters raise immune response, British study says

A British study involving seven COVID-19 vaccines has found that they all significantly increase immune response when used as boosters and that the Pfizer-BioNTech vaccine worked so well it could be given in half doses to increase global supplies.

Many governments around the world have been racing to launch booster-shot campaigns in the wake of the emergence of the Omicron variant, which was detected by South African scientists last week. There are concerns the new variant could be more transmissible than the Delta mutation, which has become the dominant version of the virus in most countries.

The British study involved 2,878 people from across Britain who received two doses of either the Oxford-AstraZeneca or the Pfizer vaccines for their initial vaccinations. Participants were divided into groups and given booster shots after 10 to 12 weeks of either AstraZeneca, Pfizer, Novavax, Janssen-Johnson & Johnson, Moderna, Valneva or CureVac, which was withdrawn from development in October.

The T-cell response to the Delta and Beta variants was particularly encouraging, the scientists added. These cells work with antibodies and they also attack and clear cells that have been infected. And while antibody levels decline over time, T-cells can remain in the bloodstream much longer and serve as a surveillance mechanism to detect any reinfection.

Another study published on Thursday, in the U.S. journal Science Advances, pinpointed how a rare type of blood clotting has occurred in people after they received a first dose of the AstraZeneca vaccine.

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