The pill was just 37% effective at preventing hospitalization or death in high-risk patients when compared to no Covid treatment at all, according to an observational study published Thursday in JAMA Network Open. In earlier studies, it cut the risk of hospitalization or death by as much as 89%.
The study published Thursday measures how the drug is performing in the real world, rather than carefully designed and monitored clinical trials. Both the earlier trial and the newer study measured people at high risk of developing Covid complications. Despite the lower efficacy against hospitalization and death in the new study, the antiviral is still “definitely recommended for high-risk patients,” says Danyu Lin, a biostatistics professor at the University of North Carolina at Chapel Hill and lead author of the study.
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