Epileptic seizures, the majority of which originate in the hippocampus, involve nerve cells in one part of the brain repeatedly firing together in synchrony before that hyperactivity possibly spreads to other areas. This can result in symptoms such as loss of consciousness and convulsions.
As such, researchers monitored split-second changes in levels of 2-AG in the hippocampus of mice during both normal activity and seizure-induced periods.Photo by Stanford University School of Medicine This fast breakdown means existing biochemical methods are too slow to measure their levels in animals’ brains. But using a modified version of CB1 that emits a fluorescent glow allowed investigators to see changes correlating with endocannabinoid levels where binding was occurring.
But because the substance is almost immediately converted to arachidonic acid, a building block for inflammatory compounds, this led to constriction of tiny blood vessels in the brain and cut off oxygen supply to parts of the brain.
Source: Education Headlines (educationheadlines.net)
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