Hemsworth, best known for his role as Thor in the Marvel movies, has the APOE e4 gene, which increases the risk of developing Alzheimer's earlier in life.fAlzheimer’s disease is a chronic condition that is believed to be the result of the accumulation of certain proteins in the brain that leads to the slow death of neurons,. This process eventually produces symptoms of memory loss, difficulty thinking or changes in mood and behaviour.
The reason for the uncertainty is that it is difficult to measure NAD+ levels in the brain. New MRI techniques provide useful information but are expensive and offer only indirect measurements. Instead, the team measured NAD+ by looking at extracellular vesicles — tiny particles in the blood that originated from neurons. By using these vesicles as a new form of blood-based biomarker for brain disorders, the team could essentially view a “liquid biopsy” of the brain’s neurons.
They also found a correlation between these neurodegenerative biomarkers and changes in NAD+. “If NAD+ went up a lot, there was typically a larger change in some of the disease biomarkers,” Martens said. “That tells us the NAD+ is not only getting into the brain but it’s likely also having some effect on its metabolism and multiple interrelated pathways.”
“They’re coming in with cognitive deficits and as a result are more likely to have an accumulation of some of these biomarkers in their brain, so there’s a chance we’ll see bigger reductions in these biomarkers because they have more of them in their cells,” Martens said.
Source: Healthcare Press (healthcarepress.net)
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