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are immunotherapy drugs that block crucial proteins from binding to cancerous tumors, meaning the immune system's T cells can more easily recognize and kill theoff. They are a good idea in theory, especially as the drugs are less toxic than chemotherapy, but scientists are trying to find ways to increase the impact of this approach in practice.
In the US, several checkpoint inhibitor therapies are currently approved for human use, but while these drugs can treat a wide variety of cancers, they, the 24-hour circadian clock cycle affected both the strength of the defenses put up by tumors, and the ability of checkpoint inhibitors to fight them.
What's more, when the circadian rhythm was disrupted in the mice, it reduced the immune system's ability to tackle cancer. This, together withSecond, was the finding that body clock disruption increased these cells even further, helping the cancer to progress. Third, the checkpoint inhibitor treatments were found to work best when the immunosuppressive cell levels were at their peak.
"As we enhance our understanding of the fundamental mechanism of circadian regulation of immunity, we will be able to harness the power of the body's natural rhythms to fight cancer and develop more personalized and effective treatment strategies,"
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