A recent study from Yale indicates that additional chromosomes in cancer cells are essential for the growth of tumors. Removing these extra chromosomes inhibits tumor formation. The findings, said the researchers, indicate that selectively targeting extra chromosomes may offer a new route for treati
A new study shows that cancer cells with extra chromosomes rely on those additional chromosomes for tumor growth, and removing them halts tumor formation. The research opens a potential new avenue for cancer treatment by selectively targeting these extra chromosomes.indicates that additional chromosomes in cancer cells are essential for the growth of tumors. Removing these extra chromosomes inhibits tumor formation.
“For a long time, we could observe aneuploidy but not manipulate it. We just didn’t have the right tools,” said Sheltzer, who is also a researcher at Yale Cancer Center. “But in this study, we used the gene-engineering technique CRISPR to develop a new approach to eliminate entire chromosomes from cancer cells, which is an important technical advance. Being able to manipulate aneuploid chromosomes in this way will lead to a greater understanding of how they function.
“When we eliminated aneuploidy from the genomes of these cancer cells, it compromised the malignant potential of those cells and they lost their ability to form tumors,” said Sheltzer. This overexpression of certain genes also pointed the researchers to a vulnerability that might be exploited to target cancers with aneuploidy., is required to activate certain drugs.
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