Why have placebos become more effective in recent years? And why are they working even in patients who know they're receiving a placebo?
Not everyone benefits—the impact of placebos varies from one person to the next. This may be a genetic trait. One studythat a particular gene variation makes people more sensitive to IBS pain and those same people were more likely to find relief from a fake acupuncture treatment.
At the University of Alabama in Birmingham, researchers explored the impact of the same gene on cancer-related fatigue and that it promoted relief in response to an open-label placebo. The gene provides instructions to brain nerve cells to produce a particular enzyme.how the brain operates to produce beneficial responses to a placebo. Doctors and patients—and of course, parents—know that when sick people hear “This is going to make you feel better” and trust the speaker, they are more likely to have a good response than if they aren’t reassured or don’t believe what they hear.
There is some debate about whether placebos work in people who have Alzheimer’s disease. The disease impairs the prefrontal cortex, which is associated with thinking, behavior, and emotions, and people with the condition may be unable to develop expectations when they take a pill. However the Alzheimer’s Association
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