Pfizer, GSK and Moderna are ahead in the race to produce vaccines against respiratory syncytial virus — what will be their impact?
that the virus uses to anchor to and enter human cells paved the way for the current wave of RSV vaccines.Moderna’s mRNA-based vaccine stimulates the production of a stabilized version of this protein, whereas the Pfizer and GSK vaccines inject synthetic versions of it directly. In trials, their efficacies have been remarkably similar, although Bont expects differences to emerge in their initial protection they offer and the durability of immunity after they are rolled out on a larger scale.
Although initial COVID-19 vaccination rates were high in older people, Christine Shaw, vice-president and portfolio head for respiratory vaccines at Moderna, in Cambridge Massachusetts, says “that was a pandemic emergency”. For RSV, “the awareness and the fear, it's not the same”. Uptake of COVID-19 boosters has fallen off in older populations and influenza jabs are often not as popular as public-health experts would like.
“I think that in ten years, we’re going to talk about the RSV vaccine in moms, and we’re going to look back and say, ‘Look at what this moment in public-health history was’,” says Alejandra Gurtman, vice-president, vaccine clinical research and development at Pfizer, in New York City.
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