Vaccines are highly effective at protecting against infectious diseases, but not everyone responds equally well to them. There are various factors that can affect a person's immune response to vaccination, including specific biomarkers within the immune system. However, it has not previously been cl
Vaccines are a vital tool in public health, protecting individuals and communities from serious and potentially deadly diseases. They work by introducing a small, safe version of a disease-causing virus or bacteria into the body, triggering an immune response. This response results in the production of antibodies, which can then recognize and attack the real disease-causing agent if it is encountered in the future.
The participants were separated into three endotypes, or groups with a common gene expression, based on the level of inflammatory response prior to vaccination — a high-inflammatory group, a low-inflammatory group, and a mid-inflammatory group. After studying the immunological changes that occurred in participants following vaccination, researchers found the group that had the highest levels of inflammation prior to the vaccine had the strongest antibody response.
“With the knowledge we now have about what characteristics of the immune system enable a more robust response, vaccines can be tailored to induce this response and maximize their effectiveness,” says Fourati. “But we still have more questions to answer.”
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