Scientists have found an extremely subtle twist in the genetics of aging cells, one that seems to make them increasingly less functional as time goes on.
animals like mice, rats, killifish, and even humans show a gradual imbalance of long and short genes in virtually every cell in their body as they age.
"We have been primarily focusing on a small number of genes, thinking that a few genes would explain disease,""So, maybe we were not focused on the right thing before. Now that we have this new understanding, it's like having a new instrument. It's like Galileo with a telescope, looking at space. Looking at gene activity through this new lens will enable us to see biological phenomena differently.
In several different types of animals, in fact, shorter transcriptomes were found to proliferate with age. In rats, tissue samples taken at 4 months of age had a relatively longer median length of genes than those taken at 9 months of age.To test the pattern in humans, researchers turned to data from the project, which publicly provides genetic information collected from almost 1,000 deceased individuals.
"The result for humans is very strong because we have more samples for humans than for other animals,""It was also interesting because all the mice we studied are genetically identical, the same gender, and raised in the same laboratory conditions, but the humans are all different. They all died from different causes and at different ages. We analyzed samples from men and women separately and found the same pattern.
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