Science, Space and Technology News 2024
have advanced kidney research by developing a new method to cultivate nephron progenitor cells from human stem cells. This method simplifies the process and enhances applications in disease modeling and drug discovery., USC scientists report significant progress in cultivating nephron progenitor cells , the cells destined to form the kidney’s filtration system, the nephrons. NPCs hold immense promise for understanding kidney development, modeling diseases, and discovering new treatments.
This improved cocktail enables the sustained growth of both mouse and human NPCs in a simple 2-dimensional format. This marks a major improvement over the previous 3-dimensional system, which was not only more cumbersome, but also limited the ability to perform genome editing on the cells. Moreover, the cocktail is powerful enough to reprogram a differentiated type of kidney cell known as a podocyte into an NPC-like state.
In a further demonstration, the scientists introduced the genetic mutations responsible for polycystic kidney disease into the NPCs. These NPCs developed into mini-kidney structures, known as organoids, exhibiting cysts—the hallmark symptom of PKD. The team then used the organoids to screen for drug-like compounds that inhibited cyst formation.
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