Science, Space and Technology News 2023
Metformin, a widely prescribed drug for type 2 diabetes, not only reduces blood sugar levels but has also been shown to increase the lifespan of, a founding member of the Mass General Brigham healthcare system, reveals that metformin promotes longevity by stimulating the body’s production of molecules called ether lipids, a major structural component of cell membranes.
The experiments reveal that genes that increase the production of ether lipids are required to extend lifespan in response to the biguanides. Inactivation of the genes that encode for these enzymes completely prevented the longevity-promoting effects of biguanides. Importantly, the inactivation of these genes prevented lifespan extension in a variety of situations that are also known to promote longevity, including dietary restriction.The team also found that increasing ether lipid synthesis alone , epidemiological observation, and rigorous clinical trials are required to determine the viability of promoting ether lipid synthesis to promote human health-span and lifespan.
Reference: “Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans” by Lucydalila Cedillo, Fasih M Ahsan, Sainan Li, Nicole L Stuhr, Yifei Zhou, Yuyao Zhang, Adebanjo Adedoja, Luke M Murphy, Armen Yerevanian, Sinclair Emans, Khoi Dao, Zhaozhi Li, Nicholas D Peterson, Jeramie Watrous, Mohit Jain, Sudeshna Das, Read Pukkila-Worley, Sean P Curran and Alexander A Soukas, 22 August 2023,This work was funded by NIH/NIA Grants...
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
The Secrets to Healthy Aging According to Longevity ExpertsOprah and Ralph sat down to talk about gratitude, dreaming big, and embracing growing older for The Life You Want Class: A Conversation with Sheryl Lee Ralph.
Read more »
Unlocking BABA-induced resistance in tomato: A comprehensive multi-omics analysisPlants have always been susceptible to various environmental stresses and attacks by pests and pathogens. Over time, they have evolved multiple defense mechanisms to repel potential attackers.
Read more »
Unlocking the Power of Advanced Virtual Private Cloud Peering on AWSAmazon's virtual private cloud peering allows for internal network connectivity that is both robust and efficient.
Read more »
Unlocking the power of peas: Genetic discovery promises high-iron vegetables and cerealsA genetic breakthrough has opened new opportunities for iron-fortified vegetables and cereal crops to help address the global health issue of anemia.
Read more »
Unlocking the genetic potential of poplars: A new era of precision genome editing with CRISPRThe Populus genus, commonly known as poplars, cottonwoods, and aspens, consists of approximately 30 tree species native to the northern hemisphere. Because of their diverse usages in landscape, agriculture, bioenergy, and industry, Populus species have been the focus of many tree breeding and genetic improvement programs.
Read more »
3 Keys To Longevity In The Startup WorldCEO and cofounder of Wistia. Read Chris Savage's full executive profile here.
Read more »