DNA damage drives premalignant immune cells in skin to form leukaemia.
investigate the development of an aggressive form of leukaemia called blastic plasmacytoid dendritic cell neoplasm , which is often diagnosed by the presence of malignant cells in the skin.
The authors’ data show that the migration of a type of immune cell through the skin leads to the accumulation of DNA damage associated with exposure to ultraviolet light. This damage precedes the acquisition of mutations associated with the transformation to malignancy, indicating that movement of pre-leukaemic cells to the skin is involved in the early stages of BPDCN.
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