Tua Tagovailoa threw for 466 yards and three touchdowns and Tyreek Hill had 215 yards and two scores in an explosive Week 1 win for the Dolphins.
Chargers coach Brandon Staley prioritized upgrading the running game when he hired Kellen Moore as offensive coordinator. They led the league in rushing in the preseason and then ran for 234 yards on Sunday.
It also was Los Angeles' first fumble recovery on the opening defensive drive of the season in 11 years. Tagovailoa connected with Waddle for 22 yards, and Miami got into field-goal range when Chargers cornerbackwas called for pass interference on a deep pass on what would have been the final play of the half.
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