'Treatment holiday' in prostatecancer with tailored dosing MedX
Monitoring early-response biomarkers in patients receiving lutetium-177 and that overall survivalIn the current study, Nguyen and colleagues used composite early biomarkers of PSA, imaging withLu-PSMA SPECT, and diagnostic CT to guide a personalized dosing interval strategy for patients with metastatic castrate-resistant prostate cancer receivingLu-PSMA.
The men were divided into three groups on the basis of their level of response. Group 1, which included 35% of participants, achieved a significant reduction in PSA levels and a partial response onLu-SPECT. These patients were advised to discontinue treatment until PSA levels increased. This treatment holiday lasted a median of about 6 months.
Group 3 demonstrated rising PSA levels and progressive disease on SPECT imaging. These men were offered an alternative therapy.
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