Trastuzumab deruxtecan exhibits the highest objective response rate in patients with HER2+ metastatic BreastCancer, but clinical activity is also observed in patients with HER2- or non-expressing tumors fermosele FAndreMD GustaveRoussy BCSM
). HER2 staining on biopsies at progression was performed centrally at Gustave Roussy using the 4B5 pre-diluted kit , according to the manufacturer’s protocol. Twenty-five pairs of tumor biopsies obtained at baseline and progression were assessed .
Regarding T-DXd distribution during treatment, 10 paired baseline and on-treatment tumor biopsies were initially selected. Three pairs were not analyzed owing to the lack of tumor cells. Seven pairs of tumor biopsies, four from cohort 2 and three from cohort 3 , were stained.
Multiplex immunofluorescence was performed with the Ultivue kit containing the Immuno8 FixVUE panel composed of eight pre-diluted antibodies + DAPI ready to use. The antibodies were directed against CD3 , CD4 , CD8 , CD68 , FoxP3 , PD-1 , PD-L1 and PanCK/SOX10 . Thirty-one paired FFPE tumor biopsies obtained at baseline and on days 22–43 after cycle 1 were stained .
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