Soft-tissue sarcomas alter the biology of immune cells around tumors, promoting tumor development Cedars-Sinai Medical Center researchers have found that cancerous tumors known as soft-tissue sarcomas release a protein that causes immune cells to change their behavior from tumor-attacking to tumor-
The researchers discovered that tumors can “recruit” immune cells, switching them from tumor-attacking to tumor-promoting.have found that cancerous tumors known as soft-tissue sarcomas release a protein that causes immune cells to change their behavior from tumor-attacking to tumor-promoting. The work, which was recently published in the peer-reviewed journalJlenia Guarnerio, Ph.D., senior author of the study.
Soft-tissue sarcoma is a rare cancer that develops in muscle, fat, blood vessels, nerves, tendons, and joint lining. The American Cancer Society estimates that it kills over 5,000 Americans annually and that it most frequently affects the arms, legs, and abdomen. When the investigators generated tumors from cancer cells that didn’t express MIF, myeloid cells were able to penetrate the tumors, and tumor growth was reduced.
“Recurrent and aggressive soft-tissue sarcoma has proved resistant to our existing therapies,” said Dan Theodorescu, MD, Ph.D., director of Cedars-Sinai Cancer. “Yet interventions aimed at targeting components of the tumor microenvironment, which have shown promise against many solid tumors, have been only marginally tested in soft-tissue sarcoma. This work may pave the way for much more effective interventions.
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