Resistance Training May Prevent or Delay Alzheimer’s Disease, Study Suggests
responsible for a buildup of beta-amyloid plaques, a kind of toxic protein, in the brain. This buildup damages brain cells and is a key marker of Alzheimer’s disease.
The mice were trained to climb a steep-incline ladder while loads were attached to their tails corresponding to 75%, 90%, and 100% of their body weight. The experiment mimicked typical resistance training you can see humans performing in the gym. After a four-week period of training, blood samples were taken to measure levels of corticosterone, the hormone in mice equivalent to cortisol in humans; for which rising levels in response to stress heighten the risk of developing Alzheimer’s.
Levels of the hormone were normal in the exercise-trained mice, meaning their levels were equal to those found in the control group consisting of mice without the genetic mutation. Analysis of their brain tissue also showed a decrease in the formation of beta-amyloid plaques. “This confirms that physical activity can reverse neuropathological alterations that cause clinical symptoms of the disease,” said Henrique Correia Campos, first author of the article, in aThe researchers also observed the mice’s behavior to assess their anxiety and found that resistance exercise reduced levels of restlessness and agitation to similar levels to the controls, said Deidiane Elisa Ribeiro, co-first author of the article and a researcher at IQ-USP’s Neuroscience Laboratory, said in...
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