The possible role of the endometrial microbiome as an immune modulator in the phase of implantation and during pregnancy IJMS_MDPI microbiome microbiota immune immunesystem pregnancy
By Bhavana KunkalikarFeb 8 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in the International Journal of Molecular Sciences, researchers reviewed the impact of endometrial microbiota on immune tolerance during pregnancy.
Variation of endometrial microbiota across the lifespan In the present study, researchers reviewed the data on the molecular pathways by which endometrial bacteria may interact with the immunological system. Acinetobacter, Comamonadaceae, Pseudomonas, and Cloacibacterium were also dominant in the endometrial microbiome of 25 Italian women undergoing hysterectomy due to fibroids. Furthermore, the researchers hypothesized that microbes including Acinetobacter, Cutibacterium, Corynebacterium, Escherichia, Streptococcus, and Staphylococcus might comprise the core of the endometrial microbiome, while Lactobacillus had an abundance rate of less than 16%.
There are numerous strategies by which embryos can evade the immunological response to alloantigens. Most polymorphic MHC class Ia antigens are absent from the trophoblast cell surface. MHC class II antigens are also not expressed. In this scenario, most MHC class Ia and class II molecules are down-regulated just before implantation. Nonetheless, maternal immunological tolerance is also maintained when the paternal MHC is re-expressed artificially.
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