Hidradenitis suppurativa (HS) is an immune disease that affects up to 4% of the global population and causes painful, recurring skin lesions and inflammation, primarily in the folds of the skin. It commonly affects women of African American descent.
Hidradenitis suppurativa is an immune disease that affects up to 4% of the global population and causes painful, recurring skin lesions and inflammation, primarily in the folds of the skin. It commonly affects women of African American descent.
Shahid Mukhtar and his team -- Bharat Mishra, Nilesh Kumar and graduate student YiFei Gou -- used single-cell sequencing techniques to pinpoint CD2 as a key immune receptor with elevated expression on T cells and innate lymphoid cells , including natural killer cells, in HS-affected skin tissue. This finding suggests that blocking CD2 may effectively reduce the inflammatory response in HS, providing a potential new therapeutic avenue for managing symptoms and improving patient quality of life.
"Our integrative approach, combining single-cell data with molecular insights, shows the transformative potential of multiomics in discovering novel therapeutic targets," Mukhtar said."These findings deepen our understanding of HS and open new pathways for developing targeted therapies in HS and other immune-related conditions."Mahendra Pratap Kashyap, Bharat Mishra, Rajesh Sinha, Lin Jin, YiFei Gou, Nilesh Kumar, Kayla F.
Diseases And Conditions Psoriasis Skin Care Lymphoma Human Biology Personalized Medicine Skin Cancer
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