Study reveals how cleft lip is caused by a combination of genes and environment

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Study reveals how cleft lip is caused by a combination of genes and environment
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Study reveals how cleftlip is caused by a combination of genes and environment uclnews NatureComms

, has revealed for the first time how genetic and environmental factors come together to form a cleft lip or palate in a developing fetus., is the most common craniofacial malformation seen at birth, affecting one in 700 live births. It can have devastating consequences for babies and their families, as the infants may experience difficulty feeding, speaking, and hearing, and may be at increased risk for ear infections and dental problems.

to cleft lip, and that some environmental factors such as smoking, stress, infections and malnutrition during pregnancy can also increase the risk of cleft lip. Here, for the first time we have shown how these two factors work together, and why both genetic and environmental risk factors are necessary for a child to be born with cleft lip."mutations

in the e-cadherin gene, which is known to be implicated in cleft lip, but noted that not everyone with the mutation develops a cleft lip. They reproduced this mutation in mice and frogs, which generated malformations similar to the cleft lip in humans, but only when the mice and frogs carrying the mutation were also exposed to inflammation-causing environmental factors.

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