His speech was designed to set an optimistic tone ahead of a second presidential campaign in 2024, which is expected to launch in a matter of weeks. But many Democratic voters have admitted they're concerned about his age.
Mr Biden has appealed for bipartisan efforts on cancer research, supporting veterans, and beating the"opioid and overdose epidemic".
Among those who are uninsured, the cost of insulin can be up to $900 a month - forcing many to ration or skip doses and endanger their health. The White House and new Republican House Speaker Kevin McCarthy have been at loggerheads over America's $31.4trn debt ceiling, which needs to be raised in the coming months to avoid a default.
He added:"I want to make sure this country is stronger, economically sound, energy independent, secure and accountable."
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