DISCO-MS combines three-dimensional whole-organism imaging with deep learning and ultra-high sensitivity mass spectrometry. NBThighlight
is aided by AI and robotics and yields proteome similar to fresh samples
reveals plaque heterogeneity in human coronary arterySpatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. However, methods for molecular analysis of large biological specimens imaged in 3D are lacking. Here, we present
yielded proteome data indistinguishable from uncleared samples in both rodent and human tissues. We used
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